Phelps County Sheriff Rick Lisenbe announced at least one fatality in connection to the structure fire on South Highway 63 Wednesday morning.
The identity and age of the deceased has not yet been released.
Crews are still searching for two additional occupants of the home who have been unaccounted for.
PCSO Lt. Rick Hope was also able to shed some light on the nature of the home.
He said the home is not a care facility, noting that many of the occupants are believed to have been adopted by the residents.